evolutionarily-aware medicine – Since numerous gene variants contribute to the differences in human conditions including diseases, the understanding of genetic variation beyond registering the differences and their disease associations is crucial for revealing the etiology of the diseases. It is through evolution – the process of change to the genetic diversity patterns brought upon by interaction with the environment, i.e. natural selection and random genetic drift, effects of which are manifested through differential demographic histories of human populations – that we have arrived where we are today, where some genetic variants make you predisposed to become sick, some protect you and most have probably no notable role.
Global and molecular pathway-based changes in mutation rate and type
Differences in demographic history and regional selection pressures shape predisposition to disease
Population genomics-based personalised medicine
Pharmacogenomics
Personalised medicine in cancer management of admixed populations
Minimally invasive screening for early cancer diagnostics
Minimally invasive screening methods in personalized cancer management
Progress of liquid biopsy technologies